GPA33
Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.[5][6][7]
| GPA33 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GPA33, A33, glycoprotein A33 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602171 MGI: 1891703 HomoloGene: 4245 GeneCards: GPA33 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[7]
References
- GRCh38: Ensembl release 89: ENSG00000143167 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000000544 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Heath JK, White SJ, Johnstone CN, Catimel B, Simpson RJ, Moritz RL, Tu GF, Ji H, Whitehead RH, Groenen LC, Scott AM, Ritter G, Cohen L, Welt S, Old LJ, Nice EC, Burgess AW (Mar 1997). "The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily". Proc Natl Acad Sci U S A. 94 (2): 469–74. Bibcode:1997PNAS...94..469H. doi:10.1073/pnas.94.2.469. PMC 19536. PMID 9012807.
- Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID 9245713.
- "Entrez Gene: GPA33 glycoprotein A33 (transmembrane)".
Further reading
- Hwang SH, Sohn YH, Oh HB, et al. (2007). "Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans". Arch. Pathol. Lab. Med. 131 (1): 117–21. doi:10.5858/2007-131-117-HLAAAH. PMID 17227111.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mao Z, Song S, Zhu Y, et al. (2003). "Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor". Oncogene. 22 (28): 4434–43. doi:10.1038/sj.onc.1206508. PMID 12853980. S2CID 38283384.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Johnstone CN, White SJ, Tebbutt NC, et al. (2002). "Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression". J. Biol. Chem. 277 (37): 34531–9. doi:10.1074/jbc.M204865200. PMID 12114523. S2CID 36386508.
- Moritz RL, Ritter G, Catimel B, et al. (1998). "Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium". Journal of Chromatography A. 798 (1–2): 91–101. doi:10.1016/S0021-9673(97)01031-5. PMID 9542130.
External links
- GPA33 human gene location in the UCSC Genome Browser.
- GPA33 human gene details in the UCSC Genome Browser.
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