GRB14

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[5][6]

GRB14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGRB14, growth factor receptor bound protein 14
External IDsOMIM: 601524 MGI: 1355324 HomoloGene: 3303 GeneCards: GRB14
Orthologs
SpeciesHumanMouse
Entrez

2888

50915

Ensembl

ENSG00000115290

ENSMUSG00000026888

UniProt

Q14449

Q9JLM9

RefSeq (mRNA)

NM_001303422
NM_004490

NM_016719

RefSeq (protein)

NP_001290351
NP_004481

NP_057928

Location (UCSC)Chr 2: 164.49 – 164.62 MbChr 2: 64.74 – 64.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[6]

Interactions

GRB14 has been shown to interact with Epidermal growth factor receptor,[7] Fibroblast growth factor receptor 1[8] and TNKS2.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000115290 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026888 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
  6. "Entrez Gene: GRB14 growth factor receptor-bound protein 14".
  7. Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. UNITED STATES. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
  8. Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. UNITED STATES. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090.
  9. Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.

Further reading

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