GRIP domain
In molecular biology, the GRIP domain is a conserved protein domain. The GRIP (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. It contains a completely conserved tyrosine residue.[1][2][3]
| GRIP domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of a complex of the golgin-245 grip domain with arl1 | |||||||||
| Identifiers | |||||||||
| Symbol | GRIP | ||||||||
| Pfam | PF01465 | ||||||||
| InterPro | IPR000237 | ||||||||
| SCOP2 | 1upt / SCOPe / SUPFAM | ||||||||
| |||||||||
References
- Munro S, Nichols BJ (April 1999). "The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins". Curr. Biol. 9 (7): 377–80. doi:10.1016/S0960-9822(99)80166-3. PMID 10209120. S2CID 14905585.
- Barr FA (April 1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4. doi:10.1016/S0960-9822(99)80167-5. PMID 10209123. S2CID 14404566.
- Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (April 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. S2CID 14342088.
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