GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

The GVD regimen consists of three drugs, from which its name is derived:

  1. Gemcitabine;
  2. Vinorelbine; and
  3. Doxil, a pegylated liposomal formulation of doxorubicin.

Dosing
DrugDose in transplant-naive patientsDose in post-transplant patientsModeDays
Gemcitabine1000 mg/m2800 mg/m2IV infusionDays 1, 8
Vinorelbine20 mg/m215 mg/m2IV bolusDays 1, 8
Doxil15 mg/m210 mg/m2IV infusionDays 1, 8

Repeated every 21 days (3 weeks).

References
  1. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804
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