GZMB

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[3] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

GZMB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1FQ3, 1IAU
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910 HomoloGene: 108184 GeneCards: GZMB
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,630,954 bp[1] End 24,634,267 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spleen bone marrow lymph node right lung appendix palpebral conjunctiva upper lobe of left lung bone marrow cells n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component cytosol membrane immunological synapse nucleus mitochondrion secretory granule cytoplasm Biological process cytolysis proteolysis positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway natural killer cell mediated cytotoxicity apoptotic process granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3002 n/a Ensembl ENSG00000100453 n/a UniProt P10144 n/a RefSeq (mRNA) NM_004131 NM_001346011 n/a RefSeq (protein) NP_001332940 NP_004122 n/a Location (UCSC) Chr 14: 24.63 – 24.63 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[4]