GZMB

Granzyme B is a serine protease that in humans is encoded by the GZMB gene.[3] Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.

GZMB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesGZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDsOMIM: 123910 HomoloGene: 108184 GeneCards: GZMB
Orthologs
SpeciesHumanMouse
Entrez

3002

n/a

Ensembl

ENSG00000100453

n/a

UniProt

P10144

n/a

RefSeq (mRNA)

NM_004131
NM_001346011

n/a

RefSeq (protein)

NP_001332940
NP_004122

n/a

Location (UCSC)Chr 14: 24.63 – 24.63 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[4]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000100453 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Dahl CA, Bach FH, Chan W, Huebner K, Russo G, Croce CM, Herfurth T, Cairns JS (May 1990). "Isolation of a cDNA clone encoding a novel form of granzyme B from human NK cells and mapping to chromosome 14". Hum Genet. 84 (5): 465–70. doi:10.1007/bf00195821. PMID 2323780. S2CID 22245529.
  4. "Entrez Gene: GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: S01.010
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