Galactosylxylosylprotein 3-beta-galactosyltransferase

In enzymology, a galactosylxylosylprotein 3-beta-galactosyltransferase (EC 2.4.1.134) is an enzyme that catalyzes the chemical reaction

UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
galactosylxylosylprotein 3-beta-galactosyltransferase
Identifiers
EC no.2.4.1.134
CAS no.56626-21-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are UDP-galactose and 4-beta-D-galactosyl-O-beta-D-xylosylprotein, whereas its two products are UDP and 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase. Other names in common use include galactosyltransferase II, and uridine diphosphogalactose-galactosylxylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.

References

    • Robinson JA, Robinson HC (1985). "Initiation of chondroitin sulphate synthesis by beta-D-galactosides Substrates for galactosyltransferase II". Biochem. J. 227 (3): 805–14. PMC 1144909. PMID 3924029.
    • Schwartz NB, Roden L (1975). "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans". J. Biol. Chem. 250 (13): 5200–7. PMID 1150655.
    • Bai X, Zhou D, Brown JR, Crawford BE, Hennet T, Esko JD (2001). "Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6)". J. Biol. Chem. 276 (51): 48189–95. doi:10.1074/jbc.M107339200. PMID 11551958.


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