Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase

γ-L-Glutamyl-butirosin B γ-glutamyl cyclotransferase (EC 4.3.2.6, btrG (gene)) is an enzyme with systematic name γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing).[1] This enzyme catalyses the following chemical reaction

γ-L-glutamyl-butirosin B butirosin B + 5-oxo-L-proline
γ-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase
Identifiers
EC no.4.3.2.6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.

References

  1. Llewellyn NM, Li Y, Spencer JB (April 2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain". Chemistry & Biology. 14 (4): 379–86. doi:10.1016/j.chembiol.2007.02.005. PMID 17462573.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.