Gamma-glutamyltransferase 6

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene. [5]

GGT6
Identifiers
AliasesGGT6, gamma-glutamyltransferase 6
External IDsOMIM: 612341 MGI: 1918772 HomoloGene: 51918 GeneCards: GGT6
EC number3.4.19.13
Orthologs
SpeciesHumanMouse
Entrez

124975

71522

Ensembl

ENSG00000167741

ENSMUSG00000040471

UniProt

Q6P531

Q6PDE7

RefSeq (mRNA)

NM_153338
NM_001122890
NM_001288702
NM_001288703
NM_001288704

NM_027819

RefSeq (protein)

NP_001116362
NP_001275631
NP_001275632
NP_001275633
NP_699169

NP_082095

Location (UCSC)Chr 17: 4.56 – 4.56 MbChr 11: 72.33 – 72.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).

References

  1. GRCh38: Ensembl release 89: ENSG00000167741 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000040471 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Gamma-glutamyltransferase 6". Retrieved 2016-03-11.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.