Gamma-humulene synthase

γ-Humulene synthase (EC 4.2.3.56, humulene cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (γ-humulene-forming).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate γ-humulene + diphosphate
γ-humulene synthase
Identifiers
EC no.4.2.3.56
CAS no.110639-19-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

References

  1. Steele CL, Crock J, Bohlmann J, Croteau R (January 1998). "Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and γ-humulene synthase". The Journal of Biological Chemistry. 273 (4): 2078–89. doi:10.1074/jbc.273.4.2078. PMID 9442047.
  2. Little DB, Croteau RB (June 2002). "Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases δ-selinene synthase and γ-humulene synthase". Archives of Biochemistry and Biophysics. 402 (1): 120–35. doi:10.1016/S0003-9861(02)00068-1. PMID 12051690.
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