Gelatinase A

Gelatinase A, also known as MMP2 (EC 3.4.24.24, 72-kDa gelatinase, matrix metalloproteinase 2, type IV collagenase, 3/4 collagenase, matrix metalloproteinase 5, 72 kDa gelatinase type A, collagenase IV, collagenase type IV, MMP 2, type IV collagen metalloproteinase, type IV collagenase/gelatinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln
Gelatinase A
Gelatinase A, Human
Identifiers
EC no.3.4.24.24
CAS no.146480-35-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This secreted endopeptidase belongs to the peptidase family M10.

References

  1. Murphy G, McAlpine CG, Poll CT, Reynolds JJ (September 1985). "Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 831 (1): 49–58. doi:10.1016/0167-4838(85)90148-7. PMID 2994741.
  2. Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI (May 1988). "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". The Journal of Biological Chemistry. 263 (14): 6579–87. PMID 2834383.
  3. Okada Y, Morodomi T, Enghild JJ, Suzuki K, Yasui A, Nakanishi I, Salvesen G, Nagase H (December 1990). "Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties". European Journal of Biochemistry. 194 (3): 721–30. doi:10.1111/j.1432-1033.1990.tb19462.x. PMID 2269296.
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