Geranoyl-CoA carboxylase

In enzymology, a geranoyl-CoA carboxylase (EC 6.4.1.5) is an enzyme that catalyzes the chemical reaction

ATP + geranoyl-CoA + HCO3- ADP + phosphate + 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
Geranoyl-CoA carboxylase
Identifiers
EC no.6.4.1.5
CAS no.37324-35-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, geranoyl-CoA, and HCO3-, whereas its 3 products are ADP, phosphate, and 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon–carbon bonds. The systematic name of this enzyme class is geranoyl-CoA:carbon-dioxide ligase (ADP-forming). Other names in common use include geranoyl coenzyme A carboxylase, and geranyl-CoA carboxylase. It employs one cofactor, biotin.

References

    • Seubert W, Fass E, Remberger U (1963). "Untersuchungen uber den bakteriellen Abbau von Isoprenoiden. III Reinigung und Eigenschaften der Geranylcarboxylase". Biochem. Z. 338: 265–275.


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