Glasgow Precision Oncology Laboratory

The University of Glasgow's Glasgow Precision Oncology Laboratory[1] (GPOL) is a molecular research facility that partners with the NHS and industry to perform research into the development of novel therapeutic strategies, the creation of pan-cancer genomic assays and provide knowledge transfer for healthcare systems to enable them to develop landscapes for therapeutic testing in cancer.

GPOL's integrated structure is designed to take scientific ideas through preclinical studies to translation into the clinic. GPOL combines research expertise in targeted capture and whole-genome sequencing, cancer bioinformatics and the development of patient pathways in precision oncology in routine healthcare.

GPOL performs tests for discovery work on patient tumours, including whole-genome sequencing and RNA-seq, and experiments to understand models of disease, particularly genetically engineered mouse models, by defining their genomic mutational landscapes and transcriptome, and providing molecular phenotypes for clinical trials development in oncology.

GPOL uses international data, including that collected by the International Cancer Genome Consortium (ICGC), The Cancer Genome Atlas and Pan-Cancer Analysis of Whole Genomes[2] (PCAWG), to create the suite of Glasgow Cancer Assays[3][4][5][6][7][8] (also known as the Glasgow Cancer Test and the Clinical Cancer Genome) –  standardised pan-cancer assays covering adult solid tumours and haematological cancers for use by healthcare systems and researchers worldwide.

The Glasgow Cancer Assays are currently in use for testing patients for clinical trials but, with the aim of incorporating the test in routine healthcare as part of a learning healthcare system (LHS,) are being evaluated by the UK's NHS and a network of cancer centres in Italy. The Glasgow Cancer Assays are licensed to Agilent Technologies on a non-exclusive basis for global distribution for research.

History

In 2015, pancreatic cancer surgeon-scientist Professor Andrew Biankin AO was appointed Regius Surgeon and Director of the Wolfson Wohl Cancer Research Centre, part of the Institute of Cancer Sciences at the University of Glasgow. He is Director of the Glasgow Precision Oncology Laboratory and executive director and Chairman of the International Cancer Genome Consortium (from 2018).

In 2016 Professor Biankin established the Glasgow Precision Oncology Laboratory (GPOL) at the University of Glasgow to enable translational cancer research and to advance novel therapeutic strategies for cancer for academic research and industry. GPOL is located at the Wolfson Wohl Cancer Research Centre at the University of Glasgow Garscube campus, with both wet and dry labs and a high-performance compute cluster. There is close collaboration with the CRUK Beatson Institute.

GPOL's purpose-built capacity, expertise, infrastructure and resources are designed to accelerate therapeutic development from discovery through to preclinical development and clinical implementation.

GPOL's capabilities were first used to support the Precision-Panc[9] pancreatic cancer clinical trials with  the development of a genomic test panel for screening patients in 2017.

GPOL divisions and activities

Candidate molecular processes are identified in the Therapeutic Development Division, led by Professor Biankin, where model systems are used extensively to test for efficacy of therapeutics, while looking for signals that include tumour response and survival.

When a preclinical platform of evidence is compelling enough to support testing in the clinic, it moves into the Clinical Development Division, led by Dr David Chang, for testing in clinical trials.

The Medical Genomics Division, led by GPOL's Deputy Director, Dr Susanna Cooke, develop methods for picking up the same signals in patients and deliver molecular profiling for clinical trials.

References
  1. "Glasgow Precision Oncology Laboratory". University of Glasgow Institute of Cancer Sciences. 30 April 2019.
  2. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (5 February 2020). "Pan-Cancer Analysis of Whole Genomes". Nature. 578 (7793): 82–93. Bibcode:2020Natur.578...82I. doi:10.1038/s41586-020-1969-6. PMC 7025898. PMID 32025007.
  3. Cooke, Susie (21 October 2019). "Broad Genomic Testing for Oncology Clinical Trials and Clinical Practice". GenomeWeb.
  4. Cooke, Susie (December 2019). "Groundbreaking new cancer test?". The Biomedical Scientist.
  5. University of Glasgow (5 November 2019). "New Glasgow Cancer Tests for research and clinical trials".
  6. Biankin, Andrew (5 November 2019). "Glasgow cancer tests hold promise of more clinical trials". Good Morning Scotland, BBC Radio Scotland.
  7. Cooke, Susie (5 November 2019). "New affordable tests that could determine the best way to treat cancer patients have been developed in Glasgow". NewsDrive with Mhairi Stuart, BBC Radio Scotland.
  8. Biankin, Andrew (5 November 2019). "Trial hope for cancer sufferers". The Times.
  9. "Precision-Panc". Precision-Panc. 27 March 2020.
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