SLC38A1

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.[5][6]

SLC38A1
Identifiers
AliasesSLC38A1, ATA1, NAT2, SAT1, SNAT1, solute carrier family 38 member 1
External IDsOMIM: 608490 MGI: 2145895 HomoloGene: 12745 GeneCards: SLC38A1
Orthologs
SpeciesHumanMouse
Entrez

81539

105727

Ensembl

ENSG00000111371

ENSMUSG00000023169

UniProt

Q9H2H9

Q8K2P7

RefSeq (mRNA)

NM_001166456
NM_001166458
NM_134086

RefSeq (protein)

NP_001159928
NP_001159930
NP_598847

Location (UCSC)Chr 12: 46.18 – 46.27 MbChr 15: 96.47 – 96.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001).[supplied by OMIM][6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111371 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023169 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Sep 2000). "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta". Biochem Biophys Res Commun. 273 (3): 1175–9. doi:10.1006/bbrc.2000.3061. PMID 10891391.
  6. "Entrez Gene: SLC38A1 solute carrier family 38, member 1".

Further reading


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