Glutathione amide-dependent peroxidase
Glutathione amide-dependent peroxidase (EC 1.11.1.17) is an enzyme with systematic name glutathione amide:hydrogen-peroxide oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- 2 glutathione amide + H2O2 glutathione amide disulfide + 2 H2O
| Glutathione amide-dependent peroxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.11.1.17 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme from the proteobacterium Marichromatium gracile is a chimeric protein. It contains a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus.
References
- Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ (June 2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". The Journal of Biological Chemistry. 276 (24): 20890–7. doi:10.1074/jbc.M102026200. PMID 11399772.
External links
- Glutathione+amide-dependent+peroxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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