Glycine/sarcosine N-methyltransferase

Glycine/sarcosine N-methyltransferase (EC 2.1.1.156, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine:sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine)-forming).[1][2][3] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + glycine 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction)
(1a) S-adenosyl-L-methionine + glycine S-adenosyl-L-homocysteine + sarcosine
(1b) S-adenosyl-L-methionine + sarcosine S-adenosyl-L-homocysteine + N,N-dimethylglycine
Glycine/sarcosine N-methyltransferase
Identifiers
EC no.2.1.1.156
CAS no.294210-82-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

References

  1. Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T (July 2000). "Extreme halophiles synthesize betaine from glycine by methylation". The Journal of Biological Chemistry. 275 (29): 22196–201. doi:10.1074/jbc.M910111199. PMID 10896953.
  2. Nyyssölä A, Reinikainen T, Leisola M (May 2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Applied and Environmental Microbiology. 67 (5): 2044–50. doi:10.1128/AEM.67.5.2044-2050.2001. PMC 92834. PMID 11319079.
  3. Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T (February 2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". The Journal of Biological Chemistry. 278 (7): 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265.
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