Glycochenodeoxycholate sulfotransferase

In enzymology, a glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + glycochenodeoxycholate adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate
Glycochenodeoxycholate sulfotransferase
Identifiers
EC no.2.8.2.34
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
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Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and glycochenodeoxycholate, whereas its two products are adenosine 3',5'-bisphosphate and glycochenodeoxycholate 7-sulfate.

Nomenclature

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.

References

    Further reading

    • Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI (November 1979). "Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". Journal of Lipid Research. 20 (8): 952–9. PMID 533830.
    • Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.


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