Gonadotropin-releasing hormone family

The gonadotropin-releasing hormones (GnRH) (gonadoliberin)[1] are a family of peptides that play a pivotal role in reproduction. The main function of GnRH is to act on the pituitary to stimulate the synthesis and secretion of luteinizing and follicle-stimulating hormones, but GnRH also acts on the brain, retina, sympathetic nervous system, gonads, and placenta in certain species. There seems to be at least three forms of GnRH. The second form is expressed in midbrain and seems to be widespread. The third form has been found so far only in fish. GnRH is a C-terminal amidated decapeptide processed from a larger precursor protein. Four of the ten residues are perfectly conserved in all species where GnRH has been sequenced.

Gonadotropin-releasing hormone
Identifiers
SymbolGnRH
PfamPF00446
InterProIPR002012
PROSITEPDOC00432
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Subfamilies

Human proteins containing this domain

GNRH1, GNRH2

References

  1. Sherwood N (1987). "The GnRH family of peptides". Trends Neurosci. 10 (3): 129–132. doi:10.1016/0166-2236(87)90058-0. S2CID 53188553.
This article incorporates text from the public domain Pfam and InterPro: IPR002012
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