Growing teeth

Growing teeth is a bioengineering technology with the ultimate goal to create new full molars in a person or an animal.

Chronology
  • 2002 – British scientists have learned how to grow almost whole, but feeble teeth from single cells.
  • 2007 – Japanese scientists have bred mice almost full new teeth, but without a root.
  • 2009 – from the stem cells were grown full teeth in mice, and even managed to grow a tooth root, previously it was not possible, but there is a problem, it is that grown teeth were slightly less "native" teeth.[1]
  • 2013 - Chinese scientists grow human teeth in mice using stem cells taken from human urine.[2]
  • 2015 - Growing New Teeth in the Mouth Using Stem-Cell Dental Implants [3]
  • 2018 - Protein disorder–order interplay to guide the growth of hierarchical mineralized structures.[4]

Methods
  • Outer – the tooth is grown separately and implanted in the patient.
  • Inner – the tooth is grown directly into the patient's mouth.

Regenerative Research
  • 2012 – Indian researchers found a way to cure and regenerate an infected root canal through stem cell activation. This replaces the old method of removing the tooth nerve.[5]
  • 2013 - Swiss researchers regenerate tooth enamel of early cavities using a peptide-based biomaterial.[6]

References
  1. Normile, Dennis (3 August 2009). "Researchers Grow New Teeth in Mice". Science.
  2. "Stem cells extracted from urine used to 'grow teeth' - NHS". Archived from the original on 9 March 2017. Retrieved 23 March 2014.
  3. "Growing New Teeth in the Mouth Using Stem-Cell Dental Implants". PreScouter. 26 July 2015.
  4. Elsharkawy, Sherif; Al-Jawad, Maisoon; Pantano, Maria F.; Tejeda-Montes, Esther; Mehta, Khushbu; Jamal, Hasan; Agarwal, Shweta; Shuturminska, Kseniya; Rice, Alistair; Tarakina, Nadezda V.; Wilson, Rory M.; Bushby, Andy J.; Alonso, Matilde; Rodriguez-Cabello, Jose C.; Barbieri, Ettore; del Río Hernández, Armando; Stevens, Molly M.; Pugno, Nicola M.; Anderson, Paul; Mata, Alvaro (1 June 2018). "Protein disorder–order interplay to guide the growth of hierarchical mineralized structures". Nature Communications. 9 (1): 2145. Bibcode:2018NatCo...9.2145E. doi:10.1038/s41467-018-04319-0. PMC 5984621. PMID 29858566.
  5. Dutt, Anuradha (September 2013). "Breakthrough dentistry". The Hindu.
  6. Brunton, P. A.; Davies, R. P. W.; Burke, J. L.; Smith, A.; Aggeli, A.; Brookes, S. J.; Kirkham, J. (August 2013). "Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial". British Dental Journal. 215 (4): E6. doi:10.1038/sj.bdj.2013.741. PMC 3813405. PMID 23969679.


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