Guanylate cyclase activator 2B
Guanylate cyclase activator 2B is a protein that in humans is encoded by the GUCA2B gene. [5]
| GUCA2B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | GUCA2B, GCAP-II, UGN, guanylate cyclase activator 2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 601271 MGI: 1270851 HomoloGene: 5150 GeneCards: GUCA2B | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys.
References
- GRCh38: Ensembl release 89: ENSG00000044012 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000032978 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Guanylate cyclase activator 2B". Retrieved 2017-07-04.
Further reading
- Sindić A, Hirsch JR, Velic A, Piechota H, Schlatter E (2005). "Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts". Kidney Int. 67 (4): 1420–7. doi:10.1111/j.1523-1755.2005.00219.x. PMID 15780094.
- Guo HF, Gao PJ, Li Y, Zhu DL, Wang JG (2007). "[Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis]". Zhonghua Xin Xue Guan Bing Za Zhi (in Chinese). 35 (3): 233–6. PMID 17582287.
- Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.
- Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R (2007). "Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension". Hypertens. Res. 30 (9): 789–96. doi:10.1291/hypres.30.789. PMID 18037771.
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