Gurmarin
Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre (Gurmar). It has been utilized as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet taste in rats.[2] This rat inhibition appears to have high specificity to sugar (sweetener) molecules like sucrose, glucose, and saccharin as well as the amino acid glycine.[3] As a sweet-taste-suppressing protein, Gurmarin shows signs of being reversible in nature although having little to no effect on the sweet taste sensation in humans suggesting the protein is only active on rodent sweet taste receptors.[3] ref: Appl Microbiol Biotechnol. 2012 Nov;96(3):619-30
| Gurmarin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of gurmarin, a sweet taste-suppressing polypeptide.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Gurmarin | ||||||||
| Pfam | PF11410 | ||||||||
| InterPro | IPR010485 | ||||||||
| SCOP2 | 1gur / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 112 | ||||||||
| OPM protein | 1c4e | ||||||||
| |||||||||
| Gurmarin | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | ? | ||||||
| PDB | 1c4e | ||||||
| UniProt | P25810 | ||||||
| |||||||
References
- Arai K, Ishima R, Morikawa S, et al. (April 1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425. S2CID 36794097.
- Arai K, Aimoto S, Morikawa S, Yoshimura S, Ishima R, Imoto T, Miyasaka A, Akasaka K (1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425. S2CID 36794097.
- "Gurmarin GUR_GYMSY". Uniprot.org. May 1, 1992. Retrieved May 16, 2022.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.