Guy R. Cornelis

Guy R. Cornelis is a Belgian microbiologist.

Guy R. Cornelis
Guy R. Cornelis (2011)
NationalityBelgian
Known forBacterial infectious diseases
Scientific career
FieldsMicrobiology
InstitutionsUniversité catholique de Louvain, University of Freiburg Max Planck Institute for Plant Breeding Research Biozentrum University of Basel

Life

Cornelis graduated in pharmacist, studied in Oxford, UK and received his PhD from the University of Louvain, Belgium in 1974. He studied antibiotic resistance plasmids in Bristol (UK) and transposons at the University of Freiburg and at the Max Planck Institute in Cologne, Germany. After his appointment as Professor in Louvain in 1984, he investigated bacterial pathogenesis and joined in 1991 the Christian de Duve Institute in Brussels. In 2001, he was appointed Professor of Molecular Microbiology at the Biozentrum, University of Basel, Switzerland. Since emeritus in 2012,[1] he pursues his research at the University of Namur, Belgium.[2][3]

Work

Cornelis investigates the complex mechanisms of bacterial infectious diseases. He received particular recognition for the co-discovery with H. Wolf-Watz (Umea, Sweden) of the bacterial type III secretion system (T3SS).[4][5][6] T3SS is a mechanism by which many bacteria inject a cocktail of toxins, so-called effector proteins into animal, plant or insect cells. The effectors disarm or reprogram the target cell by sabotaging the cellular signaling network. The T3SS apparatus, called injectisome, is a complex nanosyringe made of more than 25 different proteins. Since 2004, Cornelis also studies Capnocytophaga canimorsus, a bacterium from dog's mouths responsible for fatal infections in humans.

[7] Cornelis belongs to the world’s most cited scientists.[8][9]

Awards and honors

References
  1. "Emeriti, Biozentrum, University of Basel". biozentrum.unibas.ch/. Retrieved 2014-01-07.
  2. "Curriculum Vitae". unamur.be/. Retrieved 2014-01-07.
  3. "Biography of Guy R. Cornelis". biozentrum.unibas.ch. Retrieved 2014-01-07.
  4. Cornelis, Guy R; Wolf-Watz, H (31 October 2003). "The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells". Molecular Microbiology. 23 (5): 861–867. doi:10.1046/j.1365-2958.1997.2731623.x. PMID 9076724. S2CID 20534412.
  5. Cornelis, Guy R (4 November 2006). "The type III secretion injectisome". Nat Rev Microbiol. 4 (11): 811–825. doi:10.1038/nrmicro1526. PMID 17041629. S2CID 29012981.
  6. Diepold, Andreas; Wiesand, Ulrich; Amstutz, Marlise; Cornelis, Guy R. (2012-07-13). "Assembly of the Yersinia injectisome: the missing pieces". Molecular Microbiology. 85 (5): 878–892. doi:10.1111/j.1365-2958.2012.08146.x. PMID 22788867. S2CID 22130173. Retrieved 2022-02-08.
  7. Shin, Hwain; Mally, Manuela; Meyer, Salome; Fiechter, Chantal; Paroz, Cécile; Zaehringer, Ulrich; Cornelis, Gus R (June 2009). "Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes". Infect. Immun. 77 (6): 2262–2271. doi:10.1128/IAI.01324-08. PMC 2687352. PMID 19307219.
  8. "The people behind the most influential publications". highlycited.com/. Retrieved 2014-01-07.
  9. "Research group Guy R. Cornelis". urbm.be/. Archived from the original on 2013-11-05. Retrieved 2014-01-07.
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