GyrA RNA motif

The gyrA RNA motif is a conserved RNA structure identified by bioinformatics.[1] The RNAs are present in multiple species of bacteria within the order Pseudomonadales. This order contains the genus Pseudomonas, which includes the opportunistic human pathogen Pseudomonas aeruginosa and Pseudomonas syringae, a plant pathogen.

gyrA RNA motif
Consensus secondary structure of gyrA RNAs
Identifiers
Symbol	gyrA RNA
Rfam	RF01740
Other data
RNA type	Cis-regulatory element
Domain(s)	Pseudomonadales
PDB structures	PDBe

gyrA RNAs are always found in the presumed 5' untranslated regions of gyrA genes, which encodes a protein forming a subunit of a DNA gyrase. Resistance to the antibiotic ciprofloxacin in Pseudomonas is often achieved via mutations in the gyrA gene.[2] Because of its positioning, the gyrA RNA motif was hypothesized to be a cis-regulatory element acting up the downstream gyrA genes. However, gyrA was previously regarded as a gene whose level of expression is consistent in a wide variety of growth conditions.[3]