H1FOO

H1-8
Identifiers
Aliases	H1-8, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific, H1 histone family member O oocyte specific, H1.8 linker histone, H1FOO
External IDs	MGI: 2176207 HomoloGene: 51377 GeneCards: H1-8
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	129,551,467 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	115,927,197 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; human musculoskeletal system; ; anterior pituitary; ; muscular system; ; female reproductive system; ; spinal cord; ; muscle of leg; ; lower leg; ; ovary;
	Top expressed in
	secondary oocyte; ; extensor digitorum longus muscle; ; interventricular septum; ; plantaris muscle; ; cingulate gyrus; ; morula; ; sciatic nerve; ; soleus muscle; ; ovary; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleosomal DNA binding; double-stranded DNA binding; protein binding;
Cellular component	cytoplasm; nucleosome; extracellular exosome; nucleolus; nucleus; chromosome; female germ cell nucleus;
Biological process	nucleosome assembly; meiosis; regulation of DNA methylation; negative regulation of stem cell differentiation; regulation of transcription, DNA-templated; chromosome condensation; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	132243
	171506
	ENSG00000178804
	ENSMUSG00000042279
	Q8IZA3
	Q8VIK3
	NM_001308262; NM_153833
	NM_138311; NM_001346702
	NP_001295191; NP_722575
	NP_001333631; NP_612184
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[5][6]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[6]

It incorporates into sperm chromatin after fertilisation.[7]

References

GRCh38: Ensembl release 89: ENSG00000178804 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042279 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
"Entrez Gene: H1 histone family".
Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

Teranishi T, Tanaka M, Kimoto S, et al. (2004). "Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer". Dev. Biol. 266 (1): 76–86. doi:10.1016/j.ydbio.2003.10.004. PMID 14729479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tanaka Y, Kato S, Tanaka M, et al. (2003). "Structure and expression of the human oocyte-specific histone H1 gene elucidated by direct RT-nested PCR of a single oocyte". Biochem. Biophys. Res. Commun. 304 (2): 351–7. doi:10.1016/S0006-291X(03)00610-7. PMID 12711322.
Tanaka M, Kihara M, Hennebold JD, et al. (2005). "H1FOO is coupled to the initiation of oocytic growth". Biol. Reprod. 72 (1): 135–42. doi:10.1095/biolreprod.104.032474. PMID 15371275.
Gao S, Chung YG, Parseghian MH, et al. (2004). "Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice". Dev. Biol. 266 (1): 62–75. doi:10.1016/j.ydbio.2003.10.003. PMID 14729478.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178804 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042279 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12408966-5] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-6] "Entrez Gene: H1 histone family".

[7] Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

H1FOO

Function

References

Further reading