H1FOO

Histone H1oo is a protein that in humans is encoded by the H1FOO gene.[5][6]

H1-8
Identifiers
AliasesH1-8, osH1, H1.8, H1oo, H1 histone family member O, oocyte specific, H1 histone family member O oocyte specific, H1.8 linker histone, H1FOO
External IDsMGI: 2176207 HomoloGene: 51377 GeneCards: H1-8
Orthologs
SpeciesHumanMouse
Entrez

132243

171506

Ensembl

ENSG00000178804

ENSMUSG00000042279

UniProt

Q8IZA3

Q8VIK3

RefSeq (mRNA)

NM_001308262
NM_153833

NM_138311
NM_001346702

RefSeq (protein)

NP_001295191
NP_722575

NP_001333631
NP_612184

Location (UCSC)Chr 3: 129.54 – 129.55 MbChr 6: 115.92 – 115.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.[6]

It incorporates into sperm chromatin after fertilisation.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000178804 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042279 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (November 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. "Entrez Gene: H1 histone family".
  7. Mizusawa Y, Kuji N, Tanaka Y, et al. (March 2010). "Expression of human oocyte-specific linker histone protein and its incorporation into sperm chromatin during fertilization". Fertil Steril. 93 (4): 1134–1141. doi:10.1016/j.fertnstert.2008.11.028. PMID 19147139.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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