HIST1H2AC

Histone H2A type 1-C is a protein that in humans is encoded by the HIST1H2AC gene.[5][6][7]

H2AC6
Identifiers
AliasesH2AC6, H2A/l, H2AFL, dJ221C16.4, histone cluster 1, H2ac, histone cluster 1 H2A family member c, HIST1H2AC, H2A clustered histone 6
External IDsOMIM: 602794 MGI: 2448302 HomoloGene: 130459 GeneCards: H2AC6
Orthologs
SpeciesHumanMouse
Entrez

8334

665433

Ensembl

ENSG00000180573

ENSMUSG00000094248

UniProt

Q93077

RefSeq (mRNA)

NM_003512

NM_001177544

RefSeq (protein)

NP_003503

Location (UCSC)Chr 6: 26.12 – 26.14 MbChr 13: 21.99 – 22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

Cancer

HIST1H2AC gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[8] For this reason, HIST1H2AC is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000180573 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000094248 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H2AC histone cluster 1, H2ac".
  8. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

Further reading


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