H2AFB2

Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).[5]

H2AB2
Identifiers
AliasesH2AB2, H2A.Bbd, H2A histone family member B2, H2A.B variant histone 2, H2AFB2, H2AB3, H2A.B.1
External IDsMGI: 3644875 HomoloGene: 129517 GeneCards: H2AB2
Orthologs
SpeciesHumanMouse
Entrez

474381

624957

Ensembl

ENSG00000277858

ENSMUSG00000083616

UniProt

P0C5Z0

S4R1G7

RefSeq (mRNA)

NM_001017991

NM_001281531

RefSeq (protein)

NP_001017991

NP_001268460

Location (UCSC)Chr X: 155.38 – 155.38 MbChr X: 119.22 – 119.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000277858 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000083616 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: H2A histone family".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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