HABP2

Hyaluronan-binding protein 2 also known as factor VII activating protease (FSAP) is a protein that in humans is encoded by the HABP2 gene.[5][6][7]

HABP2
Identifiers
AliasesHABP2, FSAP, HABP, HGFAL, PHBP, NMTC5, hyaluronan binding protein 2
External IDsOMIM: 603924 MGI: 1196378 HomoloGene: 3050 GeneCards: HABP2
Orthologs
SpeciesHumanMouse
Entrez

3026

226243

Ensembl

ENSG00000148702

ENSMUSG00000025075

UniProt

Q14520

Q8K0D2

RefSeq (mRNA)

NM_004132
NM_001177660

NM_146101
NM_001329935
NM_001329936

RefSeq (protein)

NP_001171131
NP_004123

NP_001316864
NP_001316865
NP_666213

Location (UCSC)Chr 10: 113.55 – 113.59 MbChr 19: 56.28 – 56.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an extracellular serine protease which binds hyaluronic acid. It is involved in cell adhesion. The protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. Two transcript variants utilizing alternative polyA sites exist for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000148702 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025075 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M (Dec 1996). "Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem. 119 (6): 1157–65. doi:10.1093/oxfordjournals.jbchem.a021362. PMID 8827452.
  6. Romisch J (Nov 2002). "Factor VII activating protease (FSAP): a novel protease in hemostasis". Biol Chem. 383 (7–8): 1119–24. doi:10.1515/BC.2002.121. PMID 12437095. S2CID 37767393.
  7. "Entrez Gene: HABP2 hyaluronan binding protein 2".

Further reading


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