HARS

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.[5][6]

HARS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHARS1, HRS, USH3B, CMT2W, histidyl-tRNA synthetase, HARS, histidyl-tRNA synthetase 1
External IDsOMIM: 142810 MGI: 108087 HomoloGene: 1592 GeneCards: HARS1
Orthologs
SpeciesHumanMouse
Entrez

3035

15115

Ensembl

ENSG00000170445

ENSMUSG00000001380

UniProt

P12081

Q61035

RefSeq (mRNA)

NM_008214

RefSeq (protein)

NP_032240

Location (UCSC)Chr 5: 140.67 – 140.69 MbChr 18: 36.9 – 36.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins.[7] The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.[5]

Clinical significance

The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.[7]

Interactions

HARS has been shown to interact with EEF1B2[8] and EEF1G.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000170445 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001380 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: HARS histidyl-tRNA synthetase".
  6. Wasmuth JJ, Carlock LR (1986). "Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5". Somat. Cell Mol. Genet. 12 (5): 513–7. doi:10.1007/BF01539922. PMID 3464104. S2CID 28520231.
  7. Freist W, Verhey JF, Rühlmann A, Gauss DH, Arnez JG (1999). "Histidyl-tRNA synthetase". Biol. Chem. 380 (6): 623–46. doi:10.1515/BC.1999.079. PMID 10430027.
  8. Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.

Further reading


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