HBXIP

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.[5][6]

LAMTOR5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLAMTOR5, HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
External IDsOMIM: 608521 MGI: 1915826 HomoloGene: 4668 GeneCards: LAMTOR5
Orthologs
SpeciesHumanMouse
Entrez

10542

68576

Ensembl

ENSG00000134248

ENSMUSG00000087260

UniProt

O43504

Q9D1L9

RefSeq (mRNA)

NM_006402
NM_001382293

NM_026774

RefSeq (protein)

NP_006393
NP_001369222
NP_006393.2

NP_081050

Location (UCSC)Chr 1: 110.4 – 110.41 MbChr 3: 107.19 – 107.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.[6]

Interactions

HBXIP has been shown to interact with NCOA6.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000134248 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000087260 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Melegari M, Scaglioni PP, Wands JR (March 1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". Journal of Virology. 72 (3): 1737–43. doi:10.1128/jvi.72.3.1737-1743.1998. PMC 109461. PMID 9499022.
  6. "Entrez Gene: HBXIP hepatitis B virus x interacting protein".
  7. Kong HJ, Park MJ, Hong S, Yu HJ, Lee YC, Choi YH, Cheong J (November 2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.

Further reading

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