HEXIM1

Protein HEXIM1 is a protein that in humans is encoded by the HEXIM1 gene.[5][6][7]

HEXIM1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHEXIM1, CLP1, EDG1, HIS1, MAQ1, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide inducible 1, HEXIM P-TEFb complex subunit 1
External IDsOMIM: 607328 MGI: 2385923 HomoloGene: 31382 GeneCards: HEXIM1
Orthologs
SpeciesHumanMouse
Entrez

10614

192231

Ensembl

ENSG00000186834

ENSMUSG00000048878

UniProt

O94992

Q8R409

RefSeq (mRNA)

NM_006460

NM_138753

RefSeq (protein)

NP_006451

NP_620092

Location (UCSC)Chr 17: 45.15 – 45.15 MbChr 11: 103.01 – 103.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

HEXIM1 has been shown to interact with Cyclin T1[6] and Cdk9[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000186834 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000048878 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Huang F, Wagner M, Siddiqui MA (Jul 2002). "Structure, expression, and functional characterization of the mouse CLP-1 gene". Gene. 292 (1–2): 245–59. doi:10.1016/S0378-1119(02)00596-6. PMID 12119119.
  6. Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O (Jun 2003). "MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner". Mol Cell Biol. 23 (14): 4859–69. doi:10.1128/MCB.23.14.4859-4869.2003. PMC 162212. PMID 12832472.
  7. "Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1".
  8. Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O (October 2016). "An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb". Proc Natl Acad Sci U S A. 113 (45): 12721–6. Bibcode:2016PNAS..11312721K. doi:10.1073/pnas.1612331113. PMC 5111705. PMID 27791144.

Further reading


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