HGFAC

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.[5][6][7]

HGFAC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHGFAC, HGFA, HGF activator
External IDsOMIM: 604552 MGI: 1859281 HomoloGene: 1170 GeneCards: HGFAC
Orthologs
SpeciesHumanMouse
Entrez

3083

54426

Ensembl

ENSG00000109758

ENSMUSG00000029102

UniProt

Q04756

Q9R098

RefSeq (mRNA)

NM_001297439
NM_001528

NM_019447

RefSeq (protein)

NP_001284368
NP_001519

NP_062320

Location (UCSC)Chr 4: 3.44 – 3.45 MbChr 5: 35.2 – 35.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000109758 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029102 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII". J Biol Chem. 268 (14): 10024–8. doi:10.1016/S0021-9258(18)82167-6. PMID 7683665.
  6. Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin". J Biol Chem. 268 (30): 22927–32. doi:10.1016/S0021-9258(18)41615-8. PMID 8226803.
  7. "Entrez Gene: HGFAC HGF activator".

Further reading


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