HIST1H1A

Histone H1.1 is a protein that in humans is encoded by the HIST1H1A gene.[3][4][5]

H1-1
Identifiers
AliasesH1-1, H1.1, H1A, H1F1, HIST1, histone cluster 1, H1a, histone cluster 1 H1 family member a, H1.1 linker histone, cluster member, HIST1H1A
External IDsOMIM: 142709 HomoloGene: 134658 GeneCards: H1-1
Orthologs
SpeciesHumanMouse
Entrez

3024

n/a

Ensembl

ENSG00000124610

n/a

UniProt

Q02539

n/a

RefSeq (mRNA)

NM_005325

n/a

RefSeq (protein)

NP_005316

n/a

Location (UCSC)Chr 6: 26.02 – 26.02 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000124610 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Eick S, Nicolai M, Mumberg D, Doenecke D (Sep 1989). "Human H1 histones: conserved and varied sequence elements in two H1 subtype genes". Eur J Cell Biol. 49 (1): 110–5. PMID 2759094.
  4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  5. "Entrez Gene: HIST1H1A histone cluster 1, H1a".

Further reading


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