HIST1H2AG

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AG gene.[5][6][7]

H2AC11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AC11, H2A.1b, H2A/p, H2AFP, H2AG, pH2A/f, histone cluster 1, H2ag, histone cluster 1 H2A family member g, H2A clustered histone 11, HIST1H2AG, H2AC15, H2AC17, H2AC16, H2AC13
External IDsOMIM: 615012 MGI: 2448300 HomoloGene: 137349 GeneCards: H2AC11
Orthologs
SpeciesHumanMouse
Entrez

8969

319170

Ensembl

ENSG00000196787

ENSMUSG00000069309

UniProt

P0C0S8

RefSeq (mRNA)

NM_021064

NM_178184

RefSeq (protein)

NP_066408
NP_003505

Location (UCSC)Chr 6: 27.13 – 27.13 MbChr 13: 21.97 – 21.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000196787 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069309 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mannironi C, Orr A, Hatch C, Pilch D, Ivanova V, Bonner W (Jun 1994). "The relative expression of human histone H2A genes is similar in different types of proliferating cells". DNA Cell Biol. 13 (2): 161–70. doi:10.1089/dna.1994.13.161. PMID 8179821.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H2AG histone cluster 1, H2ag".

Further reading


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