HIST1H2BB

Histone H2B type 1-B is a protein that in humans is encoded by the HIST1H2BB gene.[5][6][7]

H2BC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2BC3, H2B.1, H2B/f, H2BFF, histone cluster 1, H2bb, histone cluster 1 H2B family member b, HIST1H2BB, H2B clustered histone 3
External IDsOMIM: 602803 MGI: 2448377 HomoloGene: 137348 GeneCards: H2BC3
Orthologs
SpeciesHumanMouse
Entrez

3018

319178

Ensembl

ENSG00000276410

ENSMUSG00000075031

UniProt

P33778

Q64475

RefSeq (mRNA)

NM_021062

NM_175664

RefSeq (protein)

NP_066406

NP_783595

Location (UCSC)Chr 6: 26.04 – 26.04 MbChr 13: 23.93 – 23.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).

The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000276410 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000075031 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem. 52 (4): 375–83. doi:10.1002/jcb.240520402. PMID 8227173. S2CID 42454232.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H2BB histone cluster 1, H2bb".

Further reading


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