HIST1H2BE

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BE gene.[5][6][7]

H2BC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2BC6, H2B.h, H2B/h, H2BFH, dJ221C16.8, histone cluster 1, H2be, histone cluster 1 H2B family member e, HIST1H2BE, H2B clustered histone 6, H2BC10, H2BC8, H2BC7, H2BC4
External IDsOMIM: 602805 MGI: 2448403 HomoloGene: 136773 GeneCards: H2BC6
Orthologs
SpeciesHumanMouse
Entrez

8344

319185

Ensembl

ENSG00000274290

ENSMUSG00000094338

UniProt

P62807

P10853

RefSeq (mRNA)

NM_003523

NM_178199

RefSeq (protein)

NP_003517
NP_001368918

Location (UCSC)Chr 6: 26.17 – 26.18 MbChr 13: 21.9 – 21.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000274290 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000094338 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H2BE histone cluster 1, H2be".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.