HIST1H3D

Histone H3.1 is a protein that in humans is encoded by the HIST1H3D gene.[5][6][7]

H3C4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH3C4, H3/b, H3FB, histone cluster 1, H3d, histone cluster 1 H3 family member d, HIST1H3D, H3 clustered histone 4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C1, H3C11, H3C6
External IDsOMIM: 602811 MGI: 2668828 HomoloGene: 134487 GeneCards: H3C4
Orthologs
SpeciesHumanMouse
Entrez

8351

360198

Ensembl

ENSG00000197409

ENSMUSG00000069265

UniProt

P68431

P68433

RefSeq (mRNA)

NM_003530
NM_001376937

NM_013550

RefSeq (protein)

NP_066298
NP_003520
NP_003525
NP_003527

NP_835513
NP_835514
NP_659539

Location (UCSC)Chr 6: 26.2 – 26.2 MbChr 13: 23.95 – 23.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000197409 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069265 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H3D histone cluster 1, H3d".

Further reading


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