HIST3H3

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.[3][4]

H3-4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesH3-4, H3.4, H3/g, H3FT, H3t, histone cluster 3, H3, histone cluster 3 H3, HIST3H3, H3.4 histone
External IDsOMIM: 602820 HomoloGene: 133212 GeneCards: H3-4
Orthologs
SpeciesHumanMouse
Entrez

8290

n/a

Ensembl

ENSG00000168148
ENSG00000285435

n/a

UniProt

Q16695

n/a

RefSeq (mRNA)

NM_003493

n/a

RefSeq (protein)

NP_003484

n/a

Location (UCSC)Chr 1: 228.42 – 228.43 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.[5]

References

  1. ENSG00000285435 GRCh38: Ensembl release 89: ENSG00000168148, ENSG00000285435 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Albig W, Ebentheuer J, Klobeck G, Kunz J, Doenecke D (Dec 1996). "A solitary human H3 histone gene on chromosome 1". Hum Genet. 97 (4): 486–91. doi:10.1007/BF02267072. PMID 8834248. S2CID 27799958.
  4. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  5. "Entrez Gene: HIST3H3 histone cluster 3, H3".

Further reading

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