HMCES
5-hydroxymethylcytosine binding, ES cell specific is a protein that in humans is encoded by the HMCES gene. [5]
| HMCES | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | HMCES, C3orf37, SRAPD1, DC12, 5-hydroxymethylcytosine (hmC) binding, ES cell-specific, 5-hydroxymethylcytosine binding, ES cell specific | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 618288 MGI: 1914053 HomoloGene: 6636 GeneCards: HMCES | ||||||||||||||||||||||||||||||||||||||||||||||||||
| EC number | 3.4.-.- | ||||||||||||||||||||||||||||||||||||||||||||||||||
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References
- GRCh38: Ensembl release 89: ENSG00000183624 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000030060 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: 5-hydroxymethylcytosine binding, ES cell specific". Retrieved 2018-05-16.
Further reading
- Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M (June 2014). "Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain". Neurobiol. Aging. 35 (6): 1334–44. doi:10.1016/j.neurobiolaging.2013.11.031. PMID 24387984. S2CID 25277574.
- Condliffe D, Wong A, Troakes C, Proitsi P, Patel Y, Chouliaras L, Fernandes C, Cooper J, Lovestone S, Schalkwyk L, Mill J, Lunnon K (August 2014). "Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain". Neurobiol. Aging. 35 (8): 1850–4. doi:10.1016/j.neurobiolaging.2014.02.002. PMC 4066184. PMID 24679604.
- Kraus TF, Guibourt V, Kretzschmar HA (July 2015). "5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing". J Neural Transm (Vienna). 122 (7): 1035–43. doi:10.1007/s00702-014-1346-4. PMID 25471351. S2CID 34905929.
- Zhang LY, Li PL, Wang TZ, Zhang XC (October 2015). "Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer". Arch. Gynecol. Obstet. 292 (4): 891–7. doi:10.1007/s00404-015-3704-3. PMID 25827305. S2CID 24483457.
- Biayna, Josep; Garcia-Cao, Isabel; Álvarez, Miguel M.; Salvadores, Marina; Espinosa-Carrasco, Jose; McCullough, Marcel; Supek, Fran; Stracker, Travis H. (2021-03-31). "Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells". PLOS Biology. 19 (3): e3001176. doi:10.1371/journal.pbio.3001176. PMC 8041192. PMID 33788831.</ref>
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