HMG20B

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related is a protein that in humans is encoded by the HMG20B gene.[5][6]

HMG20B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHMG20B, BRAF25, BRAF35, HMGX2, HMGXB2, PP7706, SMARCE1r, SOXL, pp8857, high mobility group 20B
External IDsOMIM: 605535 MGI: 1341190 HomoloGene: 74949 GeneCards: HMG20B
Orthologs
SpeciesHumanMouse
Entrez

10362

15353

Ensembl

ENSG00000064961

ENSMUSG00000020232

UniProt

Q9P0W2

Q9Z104

RefSeq (mRNA)

NM_006339

NM_001163165
NM_001163166
NM_010440

RefSeq (protein)

NP_006330

NP_001156637
NP_001156638
NP_034570

Location (UCSC)Chr 19: 3.57 – 3.58 MbChr 10: 81.18 – 81.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HMG20B is a high-mobility group (HMG) DNA binding protein. HMG20B contains a carboxy terminal region that is essential for cytokinesis since it regulates cell cycle progression from the G2 phase into mitosis[7] This carboxy terminal region of HMG20B interacts with the tumor suppressor protein BRCA2. A particular mutation in this region of the HMG20B gene is associated with lung cancer. This mutation interferes with the association of the HMG20B and BRCA2 proteins.[7]

Interactions

HMG20B has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000064961 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020232 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacòs M, Pujana MA, Estivill X, Peral B (Jun 2000). "HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression". Cytogenetics and Cell Genetics. 88 (1–2): 62–7. doi:10.1159/000015486. PMID 10773667. S2CID 22921110.
  6. "Entrez Gene: HMG20B high-mobility group 20B".
  7. Lee M, Venkitaraman AR (2014). "A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis". Cell Cycle. 13 (16): 2554–63. doi:10.4161/15384101.2014.942204. PMC 4614378. PMID 25486196.
  8. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7420–5. Bibcode:2002PNAS...99.7420H. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  9. Marmorstein LY, Kinev AV, Chan GK, Bochar DA, Beniya H, Epstein JA, Yen TJ, Shiekhattar R (January 2001). "A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression". Cell. 104 (2): 247–57. doi:10.1016/S0092-8674(01)00209-4. PMID 11207365. S2CID 5822368.
  10. Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (February 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
  11. Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  12. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochemical and Biophysical Research Communications. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading


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