HNRPF

Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene.[5][6]

HNRNPF
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPF, HNRPF, OK/SW-cl.23, mcs94-1, heterogeneous nuclear ribonucleoprotein F
External IDsOMIM: 601037 MGI: 2138741 HomoloGene: 21032 GeneCards: HNRNPF
Orthologs
SpeciesHumanMouse
Entrez

3185

98758

Ensembl

ENSG00000169813

ENSMUSG00000042079

UniProt

P52597

Q9Z2X1

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 43.39 – 43.41 MbChr 6: 117.88 – 117.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport.

While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRNPH. Multiple alternatively spliced variants, encoding the same protein, have been identified.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000169813 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042079 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
  6. "Entrez Gene: HNRPF heterogeneous nuclear ribonucleoprotein F".

Further reading


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