HNRPH1

Heterogeneous nuclear ribonucleoprotein H is a protein[5] that in humans is encoded by the HNRNPH1 gene.[6][7]

HNRNPH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPH1, HNRPH, HNRPH1, hnRNPH, heterogeneous nuclear ribonucleoprotein H1 (H), heterogeneous nuclear ribonucleoprotein H1
External IDsOMIM: 601035 MGI: 1891925 HomoloGene: 31318 GeneCards: HNRNPH1
Orthologs
SpeciesHumanMouse
Entrez

3187

59013

Ensembl

ENSG00000169045

ENSMUSG00000007850

UniProt

P31943

O35737

RefSeq (mRNA)

NM_001257293
NM_005520
NM_001363572

NM_021510
NM_001347487

RefSeq (protein)
Location (UCSC)Chr 5: 179.61 – 179.63 MbChr 11: 50.38 – 50.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000169045 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000007850 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Penumutchu, Srinivasa; Chiu, Liang-Yuan; Meagher, Jennifer L.; Hansen, Alexandar L.; Stuckey, Jeanne A.; Tolbert, Blanton S. (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMC 6648666. PMID 30122033.
  6. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
  7. "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

Further reading


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