HNRPH3

HNRNPH3
Identifiers
Aliases	HNRNPH3, 2H9, HNRPH3, heterogeneous nuclear ribonucleoprotein H3
External IDs	OMIM: 602324 MGI: 1926462 HomoloGene: 11012 GeneCards: HNRNPH3
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	68,343,193 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	63,024,217 bp[2]
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; canal of the cervix; ; cerebellar hemisphere; ; left lobe of thyroid gland; ; right lung; ; internal globus pallidus; ; left uterine tube; ; right lobe of thyroid gland; ; tibial nerve; ; anterior pituitary;
	Top expressed in
	saccule; ; otic placode; ; superior cervical ganglion; ; maxillary prominence; ; ganglionic eminence; ; primitive streak; ; ascending aorta; ; median eminence; ; aortic valve; ; retinal pigment epithelium;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleic acid binding; RNA binding;
Cellular component	spliceosomal complex; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; mRNA processing; RNA processing; epithelial cell differentiation; RNA splicing;
	Sources:Amigo / QuickGO
Orthologs
	3189
	432467
	ENSG00000096746
	ENSMUSG00000020069
	P31942
	n/a
NM_012207; NM_021644; NM_001322434; NM_001322436; NM_001322437;
	NM_001322438; NM_001322439; NM_001322440; NM_001322441; NM_001322442; NM_001322443; NM_001322444; NM_001322445; NM_001322446; NM_001322447; NM_001322448; NM_001322449; NM_001322450; NM_001322451; NM_001322452; NM_001322453
	NM_001079824; NM_001347457; NM_001359260; NM_001359261
NP_001309363; NP_001309365; NP_001309366; NP_001309367; NP_001309368;
	NP_001309369; NP_001309370; NP_001309371; NP_001309372; NP_001309373; NP_001309374; NP_001309375; NP_001309376; NP_001309377; NP_001309378; NP_001309379; NP_001309380; NP_001309381; NP_001309382; NP_036339; NP_067676
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.[5][6]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.

The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Multiple alternative transcript variants seem to be present for this gene and some appear to have intronic regions in the mRNA. Presently, only two transcript variants are fully described.[6]

References

GRCh38: Ensembl release 89: ENSG00000096746 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020069 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mahe D, Mahl P, Gattoni R, Fischer N, Mattei MG, Stevenin J, Fuchs JP (Feb 1997). "Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest". J Biol Chem. 272 (3): 1827–36. doi:10.1074/jbc.272.3.1827. PMID 8999868.
"Entrez Gene: HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)".

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Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Honoré B (2000). "The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene". Biochim. Biophys. Acta. 1492 (1): 108–19. doi:10.1016/s0167-4781(00)00092-0. PMID 10858537.
Mahé D, Fischer N, Décimo D, Fuchs JP (2000). "Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development". Biochim. Biophys. Acta. 1492 (2–3): 414–24. doi:10.1016/s0167-4781(00)00144-5. PMID 11004512.
Yagüe J, Vázquez J, López de Castro JA (2001). "A post-translational modification of nuclear proteins, N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide ligand". Protein Sci. 9 (11): 2210–7. doi:10.1110/ps.9.11.2210. PMC 2144492. PMID 11152131.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000096746 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020069 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8999868-5] Mahe D, Mahl P, Gattoni R, Fischer N, Mattei MG, Stevenin J, Fuchs JP (Feb 1997). "Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest". J Biol Chem. 272 (3): 1827–36. doi:10.1074/jbc.272.3.1827. PMID 8999868.

[entrez-6] "Entrez Gene: HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)".

HNRPH3

References

Further reading