HNRPH3

Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene.[5][6]

HNRNPH3
Identifiers
AliasesHNRNPH3, 2H9, HNRPH3, heterogeneous nuclear ribonucleoprotein H3
External IDsOMIM: 602324 MGI: 1926462 HomoloGene: 11012 GeneCards: HNRNPH3
Orthologs
SpeciesHumanMouse
Entrez

3189

432467

Ensembl

ENSG00000096746

ENSMUSG00000020069

UniProt

P31942

n/a

RefSeq (mRNA)

NM_001079824
NM_001347457
NM_001359260
NM_001359261

RefSeq (protein)

n/a

Location (UCSC)Chr 10: 68.33 – 68.34 MbChr 10: 63.01 – 63.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).

These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.

The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Multiple alternative transcript variants seem to be present for this gene and some appear to have intronic regions in the mRNA. Presently, only two transcript variants are fully described.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000096746 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020069 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mahe D, Mahl P, Gattoni R, Fischer N, Mattei MG, Stevenin J, Fuchs JP (Feb 1997). "Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest". J Biol Chem. 272 (3): 1827–36. doi:10.1074/jbc.272.3.1827. PMID 8999868.
  6. "Entrez Gene: HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)".

Further reading


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