HOOK1

Protein Hook homolog 1 is a protein that in humans is encoded by the HOOK1 gene.[5][6]

HOOK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOOK1, HK1, hook microtubule-tethering protein 1, hook microtubule tethering protein 1
External IDsOMIM: 607820 MGI: 1925213 HomoloGene: 9289 GeneCards: HOOK1
Orthologs
SpeciesHumanMouse
Entrez

51361

77963

Ensembl

ENSG00000134709

ENSMUSG00000028572

UniProt

Q9UJC3

Q8BIL5

RefSeq (mRNA)

NM_015888

NM_030014

RefSeq (protein)

NP_056972

NP_084290

Location (UCSC)Chr 1: 59.81 – 59.88 MbChr 4: 95.86 – 95.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the hook family of coiled coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000134709 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028572 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
  6. "Entrez Gene: HOOK1 hook homolog 1 (Drosophila)".

Further reading


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