HS3ST3A1

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.[5][6]

HS3ST3A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHS3ST3A1, 30ST3A1, 3OST3A1, 3-OST-3A, heparan sulfate-glucosamine 3-sulfotransferase 3A1
External IDsOMIM: 604057 MGI: 1333861 HomoloGene: 88735 GeneCards: HS3ST3A1
Orthologs
SpeciesHumanMouse
Entrez

9955

15478

Ensembl

ENSG00000153976

ENSMUSG00000047759

UniProt

Q9Y663

Q8BKN6

RefSeq (mRNA)

NM_006042

NM_178870

RefSeq (protein)

NP_006033

NP_849201

Location (UCSC)Chr 17: 13.49 – 13.6 MbChr 11: 64.33 – 64.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family.

It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in the liver and placenta.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000153976 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047759 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
  6. "Entrez Gene: HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1".

Further reading


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