HSD17B12

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.[5][6][7]

HSD17B12
Identifiers
AliasesHSD17B12, KAR, SDR12C1, hydroxysteroid (17-beta) dehydrogenase 12, hydroxysteroid 17-beta dehydrogenase 12
External IDsOMIM: 609574 MGI: 1926967 HomoloGene: 95094 GeneCards: HSD17B12
Orthologs
SpeciesHumanMouse
Entrez

51144

56348

Ensembl

ENSG00000149084

ENSMUSG00000027195

UniProt

Q53GQ0

O70503

RefSeq (mRNA)

NM_016142

NM_019657

RefSeq (protein)

NP_057226

NP_062631

Location (UCSC)Chr 11: 43.68 – 43.86 MbChr 2: 93.86 – 93.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000149084 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027195 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Moon YA, Horton JD (Feb 2003). "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade". J Biol Chem. 278 (9): 7335–43. doi:10.1074/jbc.M211684200. PMID 12482854.
  6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. "Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12".

Further reading


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