HTATSF1

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.[5][6]

HTATSF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHTATSF1, TAT-SF1, TATSF1, dJ196E23.2, HIV-1 Tat specific factor 1
External IDsOMIM: 300346 MGI: 1919709 HomoloGene: 40950 GeneCards: HTATSF1
Orthologs
SpeciesHumanMouse
Entrez

27336

72459

Ensembl

ENSG00000102241

ENSMUSG00000067873

UniProt

O43719

Q8BGC0

RefSeq (mRNA)

NM_001163280
NM_014500

NM_028242
NM_029371

RefSeq (protein)

NP_001156752
NP_055315

NP_082518
NP_083647

Location (UCSC)Chr X: 136.5 – 136.51 MbChr X: 56.1 – 56.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[6]

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.[7] It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2.[7]

Interactions

HTATSF1 has been shown to interact with SUPT5H[8] and GTF2F2.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000102241 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067873 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhou Q, Sharp PA (November 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
  6. "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".
  7. Corsini, Nina S.; Peer, Angela M.; Moeseneder, Paul; Roiuk, Mykola; Burkard, Thomas R.; Theussl, Hans-Christian; Moll, Isabella; Knoblich, Juergen A. (April 2018). "Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation". Cell Stem Cell. 22 (4): 543–558.e12. doi:10.1016/j.stem.2018.03.002. ISSN 1934-5909. PMID 29625069.
  8. Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (September 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462. PMID 10454543.

Further reading


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