Helper-component proteinase
Helper-component proteinase (EC 3.4.22.45, HC-Pro) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein
| Helper-component proteinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.45 | ||||||||
| CAS no. | 124566-20-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in plant RNA viruses of the Potyviridae family. HC-Pro is encoded by all potyviruses, but is absent in some members of the Ipomovirus genus.[3] HC-Pro is involved in virus transmission, virus polyprotein processing, and suppression of RNA silencing, an antiviral mechanism of plants.[4]
References
- Kasschau KD, Carrington JC (May 1995). "Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus". Virology. 209 (1): 268–73. doi:10.1006/viro.1995.1254. PMID 7747479.
- Verchot, J. (1998). "Potyvirus helper component proteinase". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. (eds.). Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 677–679.
- Pasin, Fabio; Daròs, José-Antonio; Tzanetakis, Ioannis E (2022). "Proteome expansion in the Potyviridae evolutionary radiation". FEMS Microbiology Reviews. 46 (4): fuac011. doi:10.1093/femsre/fuac011. ISSN 1574-6976. PMC 9249622. PMID 35195244.
- Valli, Adrián A.; Gallo, Araiz; Rodamilans, Bernardo; López-Moya, Juan José; García, Juan Antonio (March 2018). "The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have: The HCPro from the Potyviridae family". Molecular Plant Pathology. 19 (3): 744–763. doi:10.1111/mpp.12553. PMC 6638112. PMID 28371183.
External links
- Helper-component+proteinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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