Hepatitis C alternative reading frame stem-loop

Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.

Hepatitis C alternative reading frame stem-loop
Predicted secondary structure and sequence conservation of HCV_ARF_SL
Identifiers
SymbolHCV_ARF_SL
RfamRF00620
Other data
RNA typeCis-reg
Domain(s)Viruses
SOSO:0000233
PDB structuresPDBe

The core protein-coding region of the Hepatitis C virus (HCV) genome contains a +1 alternative reading frame (ARF) and two proposed phylogenetically conserved RNA helix-forming stem loop structures (IV and VII).[1] The proteins translated from the ARF appear to be translated during the normal viral life cycle but are not essential to virus replication.[1] The two predicted stem loops shown here (SLV and SLVI) are proposed to be important for HCV translation and repression; these stem loops are located downstream of the Internal ribosome entry site (IRES) but their functional role is unknown.[1]

See also

References
  1. McMullan LK, Grakoui A, Evans MJ, Mihalik K, Puig M, Branch AD, Feinstone SM, Rice CM (2007). "Evidence for a functional RNA element in the hepatitis C virus coregene". Proc Natl Acad Sci USA. 104 (8): 2879–2884. Bibcode:2007PNAS..104.2879M. doi:10.1073/pnas.0611267104. PMC 1815275. PMID 17299041.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.