Arkansas Highway 45

The route begins at Highway 96 in Hartford and runs north to form a concurrency with Highway 252 through Midland. Further north, the route has an Officially designated exception of 0.45 miles (0.72 km) through downtown Hackett.[6] Slightly north of this exception, Highway 45 runs on the Hackett Creek Bridge and continues north to Bonanza. The route intersects Highway 253 and curves east to form a concurrency with US 71. The highway splits from US 71 to the north and, entering Fort Smith and intersecting Highway 255 before terminating at I-540/US 71.[3]

Highway 45 begins at Highway 59 at the incorporated community of Dutch Mills, and runs east past the Bethlehem Cemetery and Twin Bridges Historic District, both on the National Register of Historic Places.[7] The route continues northeast through Clyde before passing the Pyeatte Mill Site and entering the historic community of Canehill. Continuing north, the highway meets US 62 east of Lincoln, where it terminates.[4]

The third routing of Highway 45 begins at US 71B and runs west as Lafayette Street through Fayetteville. Highway 45 runs through the Washington-Willow Historic District before a sharp left turn onto Mission Boulevard. The highway continues northeast until intersecting Highway 265 and exiting Fayetteville heading east. Passing the Son's Chapel and entering Goshen, the highway continues east through rural Washington County until entering Madison County shortly after a junction with Highway 303.[4] Highway 45 has a junction with Highway 295 before forming a concurrency with US 412 Business north through Hindsville. The route continues north, with US 412B terminating at a junction with US 412 and Highway 45 terminating at Highway 12 near Clifty.[5]