Hol44 family

The Holin Hol44 (Hol44) Family (TC# 1.E.29) is a group of transporters belonging to the Holin Superfamily V.[1] A representative list of proteins belonging to the Hol44 family from caudovirales and Bacillota can be found in the Transporter Classification Database.

One characteristic member of the Hol44 family is oenophage fOg44 (Lys44; TC# 1.E.29.2.1), which secretes an endolysin that Oenococcus oeni cells are intrinsically resistant to. Full activity of Lys44 requires dissipation of the proton motive force induced by fOg44 holin during phage infection.[2]

See also

Further reading
  • "hol44 - Hol44 - Oenococcus phage fOg44 - hol44 gene & protein". www.uniprot.org. Retrieved 2016-03-21.
  • Goh, Shan; Ong, Peh Fern; Song, Keang Peng; Riley, Thomas V.; Chang, Barbara J. (2007). "The complete genome sequence of Clostridium difficile phage phiC2 and comparisons to phiCD119 and inducible prophages of CD630". Microbiology. 153 (3): 676–685. doi:10.1099/mic.0.2006/002436-0. PMID 17322187.
  • Oki, M.; Kakikawa, M.; Nakamura, S.; Yamamura, E. T.; Watanabe, K.; Sasamoto, M.; Taketo, A.; Kodaira, K. (1997). "Functional and structural features of the holin HOL protein of the Lactobacillus plantarum phage phi gle: analysis in Escherichia coli system". Gene. 197 (1–2): 137–145. doi:10.1016/s0378-1119(97)00252-7. hdl:10098/1623. PMID 9332359.

References
  1. Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
  2. Nascimento, João Gil; Guerreiro-Pereira, Maria Carolina; Costa, Sérgio Fernandes; São-José, Carlos; Santos, Mário Almeida (2008-01-01). "Nisin-triggered activity of Lys44, the secreted endolysin from Oenococcus oeni phage fOg44". Journal of Bacteriology. 190 (1): 457–461. doi:10.1128/JB.01195-07. ISSN 1098-5530. PMC 2223723. PMID 17981964.

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