Homoaconitic acid

Homoaconitatic acid (homoaconitate) is related to aconitic acid but with one extra carbon. It is part of the α-aminoadipate pathway for lysine biosynthesis, where it is made from homocitrate by homoaconitase.[1] It is converted to homoisocitrate by homoisocitrate dehydrogenase.

Homoaconitic acid

cis-Homoaconitic acid

trans-Homoaconitic acid
Names
IUPAC names
(1Z)-1-Butene-1,2,4-tricarboxylic acid
(1E)-1-Butene-1,2,4-tricarboxylic acid
Other names
Homo-cis-aconitate; Homo-trans-aconitate
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • O=C(O)C(=CC(=O)O)CCC(=O)O
Properties
C7H8O6
Molar mass 188.135 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Murray Strassman and Louis N. Ceci (1966). "Enzymatic Formation of cis-Homoaconitic Acid, an Intermediate in Lysine Biosynthesis in Yeast". The Journal of Biological Chemistry. 241 (22): 5401–5407. doi:10.1016/S0021-9258(18)96444-6. PMID 5954805.


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